Orthogonal nanoarchitectonics of M13 phage for receptor targeted anticancer photodynamic therapy
Luca Ulfo, Andrea Cantelli, A. Petrosino, Paolo Emidio Costantini, Michela Nigro, Francesco Starinieri, Eleonora Turrini, Suleman Khan Zadran, Giampaolo Zuccheri, Roberto Saporetti, Matteo Di Giosia, Alberto Danielli, Matteo Calvaresi
Abstract
Not all viruses are bad . We developed an orthogonal approach (genetic/chemical) to engineer M13 bacteriophages as targeted vectors for efficient photodynamic killing of cancer cells.
Topics & Concepts
Photodynamic therapyEpidermal growth factor receptorInternalizationPhage displayCancer cellCapsidCancerChemistryDendrimerCancer researchBiologyReceptorPeptideBiochemistryGeneGeneticsOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesBacteriophages and microbial interactions