An engineered dual-functional peptide with high affinity to demineralized dentin enhanced remineralization efficacy <i>in vitro</i> and <i>in vivo</i>
Meng Li, Yuanyuan Tu, Wanchun Zhu, Menglin Fan, Zilin Zhou, Zhaohan Yu, Shunhua Wang, Yingming Yang, Jiyao Li, Kunneng Liang
Abstract
remineralization regimen. Furthermore, the dual functions of CYP with good biocompatibility can simultaneously bind collagen and induce nanocrystal precipitation, thereby significantly absorbing calcium and phosphorus ions to form regenerated minerals for reversing the tooth decay process in the rat caries model. Overall, the dual functional peptide CYP fabricated in this study provides an ideal and smart strategy for dentin remineralization and the treatment of caries.
Topics & Concepts
In vitroIn vivoDentinBiocompatible materialPeptideMaterials scienceRemineralisationBiophysicsDentistryBiomedical engineeringChemistryBiochemistryComposite materialMedicineBiologyEnamel paintBiotechnologyBone and Dental Protein StudiesProtein Hydrolysis and Bioactive PeptidesDental materials and restorations