Mpox virus infects and injures human kidney organoids, but responding to antiviral treatment
Pengfei Li, Zhaoyu Du, Mart M. Lamers, Roberto Incitti, Hector Tejeda-Mora, Shengbing Li, Rick Schraauwen, Thierry P. P. van den Bosch, Annemarie C. de Vries, Intikhab Álam, Bart L. Haagmans, Martin J. Hoogduijn, Qiuwei Pan
Abstract
Mpox/monkeypox virus (MPXV) belongs to the Orthopoxvirus genus of the Poxviridae family. It has a large, linear, double-stranded DNA genome. Since the first identification in 1970, MPXV is generally confined to tropical regions within African countries. Alarmingly, multi-national mpox outbreaks occurred in 2022 across a large number of non-endemic countries particularly in Europe and America 1 , 2 . Skin lesions are the most common symptom, but the infection can also cause systemic manifestations such as diarrhea, neurological and respiratory complications 1 .