Diosmetin alleviated cerebral ischemia/reperfusion injury<i>in vivo</i>and<i>in vitro</i>by inhibiting oxidative stress<i>via</i>the SIRT1/Nrf2 signaling pathway
Zhigang Mei, Lipeng Du, Xiaolu Liu, Xiangyu Chen, Huan Tian, Yihui Deng, Wenli Zhang
Abstract
Diosmetin, a bioflavonoid that is abundant in dietary sources, could attenuate cerebral ischemia/reperfusion injury by inhibiting oxidative stress via the SIRT1/Nrf2 signaling pathway both in vivo and in vitro .
Topics & Concepts
Oxidative stressMalondialdehydeSuperoxide dismutasePharmacologyReactive oxygen speciesIschemiaGlutathioneMedicineReperfusion injuryMiddle cerebral arteryChemistryAnesthesiaBiochemistryInternal medicineEnzymeSirtuins and Resveratrol in MedicineBiochemical effects in animalsNeurological Disease Mechanisms and Treatments