Intestinal microbiota modulates pancreatic carcinogenesis through intratumoral natural killer cells
Yu Qin, Rachel C. Newsome, Mark Beveridge, María Celeste Hernández, Raad Z. Gharaibeh, Christian Jobin, Ryan M. Thomas
Abstract
abiotic stool culture supernatant inhibited NK-92MI cytotoxicity, migration, and anti-cancer related gene expression. Gut microbiota promotes PDAC tumor progression through modulation of the intratumoral infiltration and activity of NK cells.
Topics & Concepts
BiologyCancer researchCarcinogenesisInnate immune systemFlow cytometryNatural killer cellImmunologyCytotoxic T cellImmune systemIn vitroCancerGeneticsBiochemistryImmune Cell Function and InteractionPancreatic and Hepatic Oncology ResearchGut microbiota and health