The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
Na Liu, Miaomiao Lin, Yan Wang
Abstract
Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. This review will help to explore promising therapeutic targets from highly dynamic ubiquitination modification processes.
Topics & Concepts
Deubiquitinating enzymeUbiquitinUbiquitin-Protein LigasesPathogenesisNeuroscienceBioinformaticsBiologyMedicineUbiquitin ligaseImmunologyGeneticsGeneUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors ResearchGenetics and Neurodevelopmental Disorders