Lead generation of cysteine based mesenchymal epithelial transition (c-Met) kinase inhibitors: Using structure-based scaffold hopping, 3D-QSAR pharmacophore modeling, virtual screening, molecular docking, and molecular dynamics simulation
Asmaa Raafat, Samar Mowafy, Sahar M. Abou‐Seri, Marwa A. Fouad, Nahla A. Farag
Topics & Concepts
PharmacophoreVirtual screeningQuantitative structure–activity relationshipLipinski's rule of fiveMolecular dynamicsComputational biologyChemistryDocking (animal)DOCKComputer scienceBioinformaticsStereochemistryComputational chemistryBiologyBiochemistryIn silicoMedicineNursingGeneComputational Drug Discovery MethodsEnzyme function and inhibitionLiver physiology and pathology