High-potency PD-1/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells
Mengyuan Dai, Yuying Shi, An-Jin Wang, Xuelian Liu, Miao Liu, Hongbing Cai
Topics & Concepts
Degradation (telecommunications)PotencyPeptideChemistryCancer researchPD-L1CancerCell biologyImmune systemBiochemistryBiologyImmunologyMedicineImmunotherapyIn vitroInternal medicineComputer scienceTelecommunicationsProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways