Combining PD-L1 inhibitors with immunogenic cell death triggered by chemo-photothermal therapy <i>via</i> a thermosensitive liposome system to stimulate tumor-specific immunological response
Jie Yu, Xidong He, Zigui Wang, Yupeng Wang, Sha Liu, Xiaoyuan Li, Yubin Huang
Abstract
The combination of ICB and ICD induced by PTT and OXA significantly promoted antigen presentation and infiltration of CTLs, which inhibited the relapse, regeneration, and metastasis of tumor cells.
Topics & Concepts
Photothermal therapyLiposomeImmunogenic cell deathCancer researchImmune systemImmunotherapyMedicineNanotechnologyMaterials scienceImmunologyNanoplatforms for cancer theranosticsImmunotherapy and Immune ResponsesImmune cells in cancer