Gene Editing Rescues In vitro T Cell Development of RAG2-Deficient Induced Pluripotent Stem Cells in an Artificial Thymic Organoid System
Cameron L. Gardner, Mara Pavel-Dinu, Kerry Dobbs, Marita Bosticardo, Paul K. Reardon, Justin Lack, Suk See De Ravin, Kent Le, Ezekiel Bello, Francesca Pala, Ottavia M. Delmonte, Harry L. Malech, Amelie Montel-Hagan, Gay M. Crooks, Oreste Acuto, Matthew H. Porteus, Luigi D. Notarangelo
Topics & Concepts
Induced pluripotent stem cellRecombination-activating geneBiologyStem cellImmune systemImmunologySevere combined immunodeficiencyRAG2ImmunodeficiencyTransplantationGenome editingHematopoietic stem cell transplantationT cellCell biologyEmbryonic stem cellGeneMedicineGeneticsCRISPRInternal medicineRecombinationCAR-T cell therapy researchVirus-based gene therapy researchCRISPR and Genetic Engineering