Effect of an Accidental Colchicine Overdose in a COVID-19 Inpatient With Bilateral Pneumonia and Pericardial Effusion
Tsanko Mondeshki, Radoslav Bilyukov, Vanyo Mitev
Abstract
A 32-year-old patient with COVID-19 pneumonia and pericardial effusion mistakenly took 15 mg of colchicine over 10 hours. He developed diarrhea that resolved two days after colchicine was stopped. Remarkably, this single overdose of colchicine, without any additional therapy, resulted in the complete recovery of bilateral pneumonia and pericardial effusion, and the patient was discharged on the hospital day 9th. This case demonstrates the possibility that high colchicine doses may have a major role and a dramatic effect in the treatment of COVID-19 patients.
Topics & Concepts
MedicineColchicinePericardial effusionPneumoniaEffusionSurgeryAccidentalCoronavirus disease 2019 (COVID-19)PneumothoraxPleural effusionDiarrheaAnesthesiaInternal medicineInfectious disease (medical specialty)PhysicsDiseaseAcousticsCOVID-19 Clinical Research StudiesInflammasome and immune disordersPericarditis and Cardiac Tamponade