Actively targeted photodynamic therapy in multicellular colorectal cancer spheroids via functionalised gold nanoparticles
Nokuphila Winifred Nompumelelo Simelane, Heidi Abrahamse
Abstract
-AuNP-Anti-GCC Ab (BNC) nanoconjugates were successfully synthesised and their photodynamic effect investigated following exposure to laser irradiation and demonstrated enhanced anticancer effects in Caco-2 cells cultivated as 3D MCTS spheroids. Our findings suggest that targeted BNC nanoconjugates can improve the efficacy of PDT and highlight the potential of 3D MCTS tumour model for evaluating of targeted PDT.
Topics & Concepts
Photodynamic therapySpheroidColloidal goldCancer researchColorectal cancerIn vitroTargeted therapyCancer cellCancerMaterials scienceNanotechnologyChemistryMedicineNanoparticleBiochemistryInternal medicineOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesNanoparticle-Based Drug Delivery