Mechanistic insights into alkaloid-based inhibition of squalene epoxidase: A combined in silico and experimental approach for targeting cholesterol biosynthesis
Emadeldin M. Kamel, Sarah I. Othman, Faris F. Aba Alkhayl, Hassan A. Rudayni, Ahmed A. Allam, Al Mokhtar Lamsabhi
Topics & Concepts
Squalene monooxygenaseIn silicoSqualeneBiosynthesisAlkaloidChemistryComputational biologyBiochemistryCholesterolStereochemistryBiologyEnzymeGeneCholesterol and Lipid MetabolismPlant biochemistry and biosynthesisComputational Drug Discovery Methods