Synthesis and cytotoxicity evaluation of DNA-interactive β-carboline indolyl-3-glyoxamide derivatives: Topo-II inhibition and in silico modelling studies
Jay Prakash Soni, G. Nikitha Reddy, Ziaur Rahman, Anamika Sharma, Akella Spandana, Regur Phanindranath, Manoj P. Dandekar, Narayana Nagesh, Nagula Shankaraiah
Topics & Concepts
CytotoxicityChemistryIn silicoApoptosisTopoisomeraseCell cultureDNABiochemistryIC50Cancer cellCytotoxic T cellStereochemistryIn vitroCancerBiologyGeneGeneticsSynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsSynthesis and Biological Evaluation