TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress
Kailiang Zhou, Zhilong Zheng, Yao Li, Wen Han, Jing Zhang, Yuqin Mao, Huanwen Chen, Wanying Zhang, Mi Liu, Ling Xie, Hongyu Zhang, Huazi Xu, Jian Xiao
Abstract
TFE3 is an important regulator in ROS-mediated autophagy dysfunction following SCI, and TFE3 may serve as a promising target for developing treatments for SCI.
Topics & Concepts
AutophagyAMPKOxidative stressCell biologyReactive oxygen speciesProgrammed cell deathFlux (metallurgy)ApoptosisBiologyChemistryKinaseProtein kinase ABiochemistryOrganic chemistryAutophagy in Disease and TherapyToxoplasma gondii Research StudiesSpinal Cord Injury Research