The Mechanobiology of Vascular Remodeling in the Aging Lung
Paul B. Dieffenbach, Aja Aravamudhan, Laura E. Fredenburgh, Daniel J. Tschumperlin
Abstract
Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how interacting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.
Topics & Concepts
MechanobiologyLungFunction (biology)BiologyMedicinePathologyNeuroscienceCell biologyInternal medicinePulmonary Hypertension Research and TreatmentsCardiovascular Health and Disease PreventionChronic Obstructive Pulmonary Disease (COPD) Research