Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK
Michael S. Lichstrahl, Craig A. Townsend, Erica K. Sinner
Abstract
)-methyl carbapenam product proceeding, therefore, by inversion of absolute configuration at C6. These data clarify an unexpected ambiguity in the recently solved substrate-bound crystal structure of TokK and have led to a stereochemically complete mechanistic proposal for both TokK and ThnK.
Topics & Concepts
CobalaminMethylationChemistryCourse (navigation)StereochemistryVitamin B12BiochemistryEngineeringGeneAerospace engineeringMetalloenzymes and iron-sulfur proteinsAmmonia Synthesis and Nitrogen ReductionMetal-Organic Frameworks: Synthesis and Applications