Waning of SARS-CoV-2 RBD antibodies in longitudinal convalescent plasma samples within 4 months after symptom onset
Josée Perreault, Tony Tremblay, Marie-Josée Fournier, Mathieu Drouin, Guillaume Beaudoin-Bussières, Jérémie Prévost, Antoine Lewin, Philippe Bégin, Andrés Finzi, Renée Bazin
Abstract
Perreault and colleagues examined antibody titers in sequential samples from serum donors recovering from COVID-19 and demonstrated that antibody titers fall over 3-4 months. These results have important implications for convalescent serum collection and seroprevalence studies.
Topics & Concepts
Convalescent plasmaAntibodySeroprevalenceVirologyTiterCoronavirus disease 2019 (COVID-19)MedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Antibody titerImmunology2019-20 coronavirus outbreakNeutralizing antibodySerologyInternal medicineDiseaseOutbreakInfectious disease (medical specialty)SARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingCOVID-19 Clinical Research Studies