Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands
Fabrizio Fierro, Lior Peri, Harald Hübner, Alina Tabor-Schkade, Lukas Waterloo, Stefan Löber, Tara Pfeiffer, Dorothée Weikert, Tamir Dingjan, Eitan Margulis, Peter Gmeiner, Masha Y. Niv
Topics & Concepts
G protein-coupled receptorVirtual screeningComputational biologyChemical libraryBitter tasteDrug discoveryChemistryReceptorFlufenamic acidPharmacologyBiochemistryBiologyTasteSmall moleculeBiochemical Analysis and Sensing TechniquesReceptor Mechanisms and SignalingRNA and protein synthesis mechanisms