Sarcopenia-related traits and coronary artery disease: a bi-directional Mendelian randomization study
Hui Li, Qıang Zhang, Wen‐Di Shen, Boyang Li, Wan‐Qiang Lv, Hong‐Mei Xiao, Hong‐Wen Deng
Abstract
= 1.10E-05). However, genetically predicted CAD did not show any causal association with handgrip strength, and no significant causal relationship was detected between genetically instrumented body lean mass and CAD. Our results suggest that decreased muscle strength but not decreased muscle mass leads to the increased risk of CAD in sarcopenia.
Topics & Concepts
Mendelian randomizationSarcopeniaCoronary artery diseaseOdds ratioInternal medicineMedicineConfidence intervalCADGenome-wide association studyCardiologySingle-nucleotide polymorphismGeneticsBiologyGenetic variantsGenotypeGeneBiochemistryNutrition and Health in AgingObesity, Physical Activity, DietGenetic Associations and Epidemiology