Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy
Irfan Ullah, Jérémie Prévost, Mark S. Ladinsky, Helen Stone, Maolin Lu, Sai Priya Anand, Guillaume Beaudoin-Bussières, Kelly Symmes, Mehdi Benlarbi, Shilei Ding, Romain Gasser, Corby Fink, Yaozong Chen, Alexandra Tauzin, Guillaume Goyette, Catherine Bourassa, Halima Medjahed, Matthias Mack, Kunho Chung, Craig B. Wilen, Gregory A. Dekaban, Jimmy D. Dikeakos, Emily A. Bruce, Daniel E. Kaufmann, Leonidas Stamatatos, Andrew T. McGuire, Jonathan Richard, Marzena Pazgier, Pamela J. Björkman, Walther Mothes, Andrés Finzi, Priti Kumar, Pradeep D. Uchil
Topics & Concepts
AntibodyEffectorVirologyImmune systemImmunologyBiologyNeutralizationNasal administrationNeutralizing antibodySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)In vivoBioluminescence imagingCoronavirus disease 2019 (COVID-19)VirusMedicineDiseaseCell cultureLuciferasePathologyInfectious disease (medical specialty)TransfectionBiotechnologyGeneticsSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing