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Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y14R antagonists with potential high efficiency against acute gouty arthritis

Ran Lu, Yilin Wang, Chunxiao Liu, Zhenguo Zhang, Baiyang Li, Zibo Meng, Cheng Jiang, Qinghua Hu

2021European Journal of Medicinal Chemistry22 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryArthritisPharmacologyBenzoic acidIn vivoAmideLead compoundInflammationBenzamideBiochemistryStereochemistryIn vitroMedicineInternal medicineBiologyBiotechnologyAdenosine and Purinergic SignalingUrticaria and Related ConditionsCardiovascular Issues in Pregnancy
Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y14R antagonists with potential high efficiency against acute gouty arthritis | Litcius