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Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1,2,3-triazole fragment that mimic quinazoline epidermal growth factor receptor inhibitors: Synthesis, antitumor and mechanistic analyses

Nadjet Rezki, Meshal A. Almehmadi, Saleh Ihmaid, Ahmed M. Shehata, Abdelsattar M. Omar, Hany E. A. Ahmed, Mohamed Reda Aouad

2020Bioorganic Chemistry97 citationsDOI

Topics & Concepts

BenzothiazoleQuinazolineChemistryIsatinEGFR inhibitorsErlotinibDocking (animal)GefitinibEpidermal growth factor receptorTriazoleIC50PharmacologyStereochemistryIn vitroBiochemistryReceptorBiologyNursingOrganic chemistryMedicineQuinazolinone synthesis and applicationsCancer therapeutics and mechanismsClick Chemistry and Applications
Novel scaffold hopping of potent benzothiazole and isatin analogues linked to 1,2,3-triazole fragment that mimic quinazoline epidermal growth factor receptor inhibitors: Synthesis, antitumor and mechanistic analyses | Litcius