The AKI care bundle: all bundle components are created equal—are they?
Thilo von Groote, Marlies Ostermann, Lui G. Forni, Melanie Meersch, Alexander Zarbock, the PrevAKI Investigators, C. G. Schmidt, A. Hoffmeier, Hugo Van Aken, Carola Wempe, Mira Küllmar, Gianluca Lucchese, Kamran Baig, Armando Cennamo, Ronak Rajani, Stuart McCorkell, Christian Arndt, Hinnerk Wulf, Marc Irqsusi, Fabrizio Monaco, Ambra Licia Di Prima, Mercedes García Álvarez, Stefano Italiano, Jordi Miralles Bagán, Gudrun Kunst, Shrijit Nair, Camilla L’Acqua, Eric A. J. Hoste, Wim Vandenberghe, Patrick M. Honoré, John A. Kellum, Philippe Grieshaber, Christina Massoth, Raphael Weis
Abstract
Purpose!#!This study aimed at investigating the mechanisms underlying the oxygenation response to proning and recruitment maneuvers in coronavirus disease 2019 (COVID-19) pneumonia.!##!Methods!#!Twenty-five patients with COVID-19 pneumonia, at variable times since admission (from 1 to 3 weeks), underwent computed tomography (CT) lung scans, gas-exchange and lung-mechanics measurement in supine and prone positions at 5 cmH!##!Results!#!The average values of venous admixture and PaO!##!Conclusion!#!The amount of consolidated tissue was higher in patients assessed during the third week and determined the oxygenation responses following pronation and recruitment maneuvers.