Prognosis of <i>MECOM</i> (<i>EVI1</i>)-rearranged MDS and AML patients rather depends on accompanying molecular mutations than on blast count
Isolde Summerer, Claudia Haferlach, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach, Anna Stengel
Abstract
The MDS1/EVI1 complex (MECOM) is located on chromosome 3q26. EVI1 is a nuclear transcription factor and represents a proto-oncogene playing an important role in leukemogenesis in myeloid malignanci...
Topics & Concepts
MedicineHematologic NeoplasmsMyelodysplastic syndromesMyeloidCancer researchInternal medicineOncologyBone marrowCancerAcute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processesMyeloproliferative Neoplasms: Diagnosis and Treatment