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LCZ696 (sacubitril/valsartan) protects against cyclophosphamide-induced nephrotoxicity in adult male rats: Up-regulation of Apelin-13/ACE2, miR-200, and down-regulation of TGF-β/SMAD 2/3 and miR-192

Samah S. Abbas, Mona F. Schaalan, Sahar M. Gebril, Fatma E. Hassan, Maha O. Mahmoud, Soha Osama Hassanin

2022Life Sciences19 citationsDOI

Topics & Concepts

ValsartanNephrotoxicityCreatinineChemistryEndocrinologyPharmacologyInternal medicineKidneyOxidative stressLactate dehydrogenaseNOX4MedicineBiochemistryEnzymeNADPH oxidaseBlood pressureApelin-related biomedical researchChemotherapy-induced organ toxicity mitigationParaoxonase enzyme and polymorphisms
LCZ696 (sacubitril/valsartan) protects against cyclophosphamide-induced nephrotoxicity in adult male rats: Up-regulation of Apelin-13/ACE2, miR-200, and down-regulation of TGF-β/SMAD 2/3 and miR-192 | Litcius