Identification of human CD4 <sup>+</sup> T cell populations with distinct antitumor activity
Michelle H. Nelson, Hannah M. Knochelmann, Stefanie R. Bailey, Logan W. Huff, Jacob S. Bowers, Kinga Majchrzak, Megan M. Wyatt, Mark P. Rubinstein, Shikhar Mehrotra, Michael I. Nishimura, Kent Armeson, Paul G. Giresi, Michael J. Zilliox, Hal E. Broxmeyer, Chrystal M. Paulos
Abstract
Human CD4 + T cell subsets elicit differential immunity against solid tumors when redirected with antigen specificity.
Topics & Concepts
Identification (biology)Computational biologyCellBiologyGeneticsEcologyCAR-T cell therapy researchImmunotherapy and Immune ResponsesT-cell and B-cell Immunology