Litcius/Paper detail

Systems redox biology in health and disease

Martin Feelisch, Miriam M. Cortese‐Krott, Jérôme Santolini, Stephen A. Wootton, Alan A. Jackson

2022PubMed32 citationsDOIOpen Access PDF

Abstract

' allows each of these to be considered as distinct but complementary aspects of the same system, representative of roles at different levels of organization within a functional hierarchy. The versatile chemistry of sulfur - exemplified by hydrogen sulfide, glutathione and proteinous cysteine thiols - enriched by its interactions with reactive oxygen, nitrogen and sulfur species, would seem to sit at the heart of the 'Redox Code' and underpin the ability of complex organisms to cope with stress.

Topics & Concepts

OrganismStressorOxidative stressLiving systemsAdaptation (eye)HierarchyDiseasePerspective (graphical)Computational biologyBiologyComputer scienceEcologyMedicineBiochemistryNeurosciencePolitical scienceGeneticsArtificial intelligenceLawPathologySulfur Compounds in BiologyRedox biology and oxidative stressVitamin C and Antioxidants Research