Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
Emma E. Watson, Francesco Russo, Dimitri Moreau, Nicolas Winssinger
Abstract
photocatalyst is applied to the rapid trans to cis isomerization of a range of alkene-containing pharmacological agents, including combretastatin A-4 (CA-4), a clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances to potent cytotoxic agents. Selective in cellulo activation of the CA-4 analog Res-3M is demonstrated, along with its potent cytotoxicity and inhibition of microtubule dynamics.
Topics & Concepts
IsomerizationCytotoxicityChemistryCombretastatinResveratrolAlkeneCytotoxic T cellStereochemistryCombinatorial chemistryMicrotubuleTubulinBiochemistryCatalysisIn vitroBiologyCell biologyPhotochromic and Fluorescence ChemistryPhotoreceptor and optogenetics research