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Gut Microbiota: An Immersion in Dysbiosis, Associated Pathologies, and Probiotics

Valentina Origüela, Alvaro Lopez-Zaplana

2025Microorganisms8 citationsDOIOpen Access PDF

Abstract

The importance of the microbiome, particularly the gut microbiota and its implications for health, is well established. However, an increasing number of studies further strengthen the link between an imbalanced gut microbiota and a greater predisposition to different diseases. The gut microbiota constitutes a fundamental ecosystem for maintaining human health. Its alteration, known as dysbiosis, is associated with a wide range of conditions, including intestinal, metabolic, immunological, or neurological pathologies, among others. In recent years, there has been a substantial increase in knowledge about probiotics-bacterial species that enhance health or address various diseases-with numerous studies reporting their benefits in preventing or improving these conditions. This review aims to analyze the most common pathologies resulting from an imbalance in the gut microbiota, as well as detail the most important and known gut probiotics, their functions, and mechanisms of action in relation to these conditions.

Topics & Concepts

DysbiosisGut floraGut microbiomeBiologyMicrobiomeProbioticHuman healthImmunologyMedicineBioinformaticsBacteriaGeneticsEnvironmental healthGut microbiota and healthProbiotics and Fermented FoodsClostridium difficile and Clostridium perfringens research
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