Sophorolipid-toluidine blue conjugates for improved antibacterial photodynamic therapy through high accumulation
Xiaoxiao Gu, Lixian Xu, Haoyang Yuan, Cailing Li, Juan Zhao, Shuang Li, Dinghua Yu
Abstract
cells of free toluidine blue. Through the cooperation of triple factors, including sophorose affinity to bacterial cells, hydrophobic association with plasma membrane, and electrostatic attraction, higher SL-TB accumulation was acquired, which has enhanced antibacterial photodynamic efficiencies.
Topics & Concepts
Photodynamic therapyToluidineConjugateChemistryCombinatorial chemistryAntibacterial activityOrganic chemistryBiologyMathematicsBacteriaMathematical analysisGeneticsPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsbioluminescence and chemiluminescence research