Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics
Jiawei Wang, Jianxia Wen, Xiao Ma, Ju Yang, Zhao Zhang, Shuying Xie, Shizhang Wei, Manyi Jing, Haotian Li, Liwei Lang, Xuelin Zhou, Yanling Zhao
Topics & Concepts
PaeoniflorinCholestasis of pregnancyMAPK/ERK pathwayCholestasisPharmacologyMetabolomicsMedicineMetabolic pathwayPI3K/AKT/mTOR pathwayTraditional Chinese medicineSignal transductionBioinformaticsChemistryBiologyInternal medicinePregnancyBiochemistryFetusMetabolismPathologyGeneticsHigh-performance liquid chromatographyAlternative medicineChromatographyDrug Transport and Resistance MechanismsLiver Disease Diagnosis and TreatmentPregnancy and preeclampsia studies