Pharmacokinetic Modeling of Warfarin І – Model-Based Analysis of Warfarin Enantiomers with a Target Mediated Drug Disposition Model Reveals CYP2C9 Genotype-Dependent Drug-Drug Interactions of S-Warfarin
Shen Cheng, Darcy R. Flora, Allan E. Rettie, Richard C. Brundage, Timothy S. Tracy
Topics & Concepts
WarfarinCYP2C9PharmacologyPharmacokineticsDrug interactionDrugCytochrome P450ChemistryMedicineInternal medicineAtrial fibrillationMetabolismPharmacogenetics and Drug MetabolismComputational Drug Discovery MethodsReceptor Mechanisms and Signaling