Ibrexafungerp Demonstrates <i>In Vitro</i> Activity against Fluconazole-Resistant Candida auris and <i>In Vivo</i> Efficacy with Delayed Initiation of Therapy in an Experimental Model of Invasive Candidiasis
Nathan P. Wiederhold, Laura K. Najvar, Marcos Olivo, Kelsey N. Morris, Hoja Patterson, Gabriel Catano, Thomas F. Patterson
Abstract
Candida auris is an emerging pathogen that has rapidly spread to many countries on multiple continents. Invasive infections caused by this species are associated with significant mortality, and treatment options are limited due to antifungal resistance.
Topics & Concepts
Candida aurisFluconazoleFungal pathogenInvasive candidiasisIn vivoMicrobiologyPathogenBiologyAntifungalMycosisCandida infectionsIn vitroImmunologyBiochemistryBiotechnologyAntifungal resistance and susceptibilityFungal Infections and StudiesFungal Biology and Applications