Inhibition of PRMT5 attenuates cerebral ischemia/reperfusion–Induced inflammation and pyroptosis through suppression of NF–κB/NLRP3 axis
Xiang Wu, Bo Wang, Jiaxi Li, Zhongbo Yang, Yunfei Zhou, Xudong Ma, Zhiyan Kou, Liangchao Jiang, Jinning Song
Topics & Concepts
Protein arginine methyltransferase 5IschemiaInflammationPharmacologyDownregulation and upregulationOxidative stressMedicineProinflammatory cytokineInflammasomePyroptosisReperfusion injuryChemistryMethylationMethyltransferaseImmunologyEndocrinologyBiochemistryInternal medicineGeneCancer-related gene regulationIntracerebral and Subarachnoid Hemorrhage ResearchEpigenetics and DNA Methylation