Mechanochemical Transformation of CF<sub>3</sub> Group: Synthesis of Amides and Schiff Bases
Satenik Mkrtchyan, Michał Jakubczyk, Suneel Lanka, Muhammad Yar, Khurshid Ayub, Mohanad Shkoor, Michael Pittelkow, Viktor O. Iaroshenko
Abstract
Abstract We communicate two mild, solvent‐free mechanochemical coupling transformations of CF 3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C−F bond activation, accompanied with utilisation of Si‐based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied. To the best of our knowledge, this work is the first example of mechanical energy promoted transformation of the inert CF 3 group into other functionalities. magnified image
Topics & Concepts
ChemistryGroup (periodic table)Transformation (genetics)Schiff baseOrganic chemistryMedicinal chemistryPolymer chemistryStereochemistryCombinatorial chemistryGeneBiochemistryFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsCarbon dioxide utilization in catalysis