Thermodynamics and structural characterization of the nickel(<scp>ii</scp>) and zinc(<scp>ii</scp>) complexes of various peptide fragments of tau protein
Bettina Diána Balogh, Györgyi Szunyog, Márton Lukács, Bence Szakács, Imre Sóvágó, Katalin Várnagy
Abstract
) complexes in alkaline solutions. The native fragment of the R3 region and its mutants containing two adjacent histidine moieties also bind only one nickel(II) ion with the His330 residue being the primary metal binding site. Exclusive binding of the independent imidazole side chains (His14 and His32 sites) cannot prevent the hydrolysis of zinc(II) in a slightly basic solution but the adjacent histidines of the R3 domain can promote the formation of amide coordinated zinc(II) complexes.
Topics & Concepts
ChemistryHistidineDeprotonationZincNickelPeptideStereochemistryCrystallographyAmideMoleculeMetalAngiotensin IIMetal ions in aqueous solutionAmino acidBiochemistryIonReceptorOrganic chemistryTrace Elements in HealthDrug Transport and Resistance MechanismsAlzheimer's disease research and treatments