Hinokitiol Protects Cardiomyocyte from Oxidative Damage by Inhibiting GSK3<i>β</i>‐Mediated Autophagy
Hongkai Xiao, Siyu Liang, Qinhong Cai, Jinghu Liu, Liang Jin, Zhengfei Yang, Xiaochao Chen
Abstract
More and more attention has been paid to the use of traditional phytochemicals. Here, we first verified the therapeutic potential of a natural bioactive compound called Hinokitiol in myocardial ischemia reperfusion injury. Hinokitiol exerts cardioprotective effect through inhibition of GSK‐3 β and subsequent elimination of excessive autophagy, tuning autophagic activity in moderate extent for remedial profit in acute myocardial infarction and myocardial ischemia reperfusion injury. Overall, our study establishes Hinokitiol as a novel available interventional treatment for myocardial ischemia reperfusion injury.
Topics & Concepts
AutophagyPharmacologyIschemiaReperfusion injuryMyocardial infarctionMedicineChemistryCardiologyApoptosisBiochemistrySpinal Cord Injury ResearchNerve injury and regenerationAutophagy in Disease and Therapy