Improved SARS-CoV-2 main protease high-throughput screening assay using a 5-carboxyfluorescein substrate
Scott Legare, Fabian Heide, Ben A. Bailey-Elkin, Jörg Stetefeld
Abstract
.
Topics & Concepts
High-throughput screeningProteaseCoronavirusDrug discoverySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Substrate (aquarium)Computational biologyFalse positive paradoxCoronavirus disease 2019 (COVID-19)ChemistryEnzymeBiologyVirologyBiochemistryMedicineComputer scienceMachine learningDiseasePathologyEcologyInfectious disease (medical specialty)Computational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchProtein Structure and Dynamics