Palladium-catalyzed <i>ortho</i> -vinylation of β-naphthols with α-trifluoromethyl allyl carbonates: one-pot access to naphtho[2,1- <i>b</i> ]furans
Chiliveru Priyanka, Muppidi Subbarao, Nagender Punna
Abstract
Highly regio- and stereoselective ortho -vinylation of β-naphthols has been accomplished via CF 3 –π-allyl Pd-complex for the first time. Next, one-pot synthesis of CF 3 -naphtho[2,1- b ]furans is developed through a oxidative radical cyclization reaction.
Topics & Concepts
ChemistryPalladiumStereoselectivityCatalysisTrifluoromethylMedicinal chemistryOxidative phosphorylationOrganic chemistryAlkylBiochemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms