Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study
Hülya Ulugut, Maxime Bertoux, Kyan Younes, Maxime Montembeault, Giorgio Fumagalli, Bedia Samancı, Ignacio Illán‐Gala, Grégory Kuchcinski, Mélanie Leroy, J. C. Thompson, Christopher Kobylecki, Alexander Santillo, Elisabet Englund, Maria Landqvist Waldö, Lina Riedl, Jan Van den Stock, Mathieu Vandenbulcke, Rik Vandenberghe, Robert Laforce, Simon Ducharme, Peter Pressman, Paulo Caramelli, Leonardo Cruz de Souza, Leonel Tadao Takada, Hakan Gürvıt, Oskar Hansson, Janine Diehl‐Schmid, Daniela Galimberti, Florence Pasquier, Bruce L. Miller, Philip Scheltens, Rik Ossenkoppele, Wiesje M. van der Flier, Frederik Barkhof, Nick C. Fox, Virginia E. Sturm, Toji Miyagawa, Jennifer L. Whitwell, Bradley F. Boeve, Jonathan D. Rohrer, Maria Luisa Gorno‐Tempini, Keith A. Josephs, Julie S. Snowden, Jason D. Warren, Katherine P. Rankin, Yolande A.L. Pijnenburg, International rtvFTD Working Group
Abstract
INTRODUCTION: Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. METHODS: Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. RESULTS: Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. DISCUSSION: This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. HIGHLIGHTS: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.