Novel cyclometalated iridium(<scp>iii</scp>) phosphine-imine (P^N) complexes: highly efficient anticancer and anti-lung metastasis agents <i>in vivo</i>
Zhishan Xu, Yuliang Yang, Xianglei Jia, Lihua Guo, Xingxing Ge, Genshen Zhong, Shujiao Chen, Zhe Liu
Abstract
Iridium(<sc>iii</sc>)-based complexes with phosphine-imine (P^N) ligands are synthesized and authenticated. The combined treatment with Ir(<sc>iii</sc>) and BIX01294 potently inhibited tumour growth and lung metastasis <italic>in vitro</italic> and <italic>in vivo</italic>.
Topics & Concepts
In vivoPhosphineIridiumImineChemistryMetastasisIn vitroCancer researchStereochemistryMedicinal chemistryBiochemistryCancerMedicineBiologyInternal medicineCatalysisBiotechnologySynthesis and Biological EvaluationMetal complexes synthesis and propertiesBrain Metastases and Treatment