Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects
Jianan Guo, Zhisheng Mi, Xiaoying Jiang, Changjun Zhang, Zili Guo, Lin-Zi Li, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie
Topics & Concepts
ChemistryMonoamine oxidaseMonoamine oxidase BIC50ChelationInhibitory postsynaptic potentialCoumarinPharmacologyLead compoundStereochemistryBiochemistryCombinatorial chemistryEnzymeIn vitroOrganic chemistryBiologyNeuroscienceMedicineAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesMedicinal Plants and Neuroprotection