Formononetin reshapes the gut microbiota, prevents progression of obesity and improves host metabolism
Mahrukh Naudhani, Kiran Thakur, Zhi‐Jing Ni, Jian‐Guo Zhang, Zhao‐Jun Wei
Abstract
; acetate and butyrate-producing bacteria. Moreover, formononetin regulated the expression of specific liver miRNA involved in obesity and down-regulated mRNA expression levels of pro-inflammatory cytokines IL-6, IL-22 and TNF-α. Additionally, FMNT maintained intestinal membrane integrity by regulating the expression of Muc-2 and occludin. Our findings indicate that FMNT could be a potential prebiotic that can effectively regulate the gut microbiota, improve host metabolism and systemic inflammation, and prevent deleterious effects of a western-style diet by elevating acetate lactate and lactate butyrate producers.
Topics & Concepts
Gut floraLachnospiraceaeFormononetinButyratePrebioticBiologyDysbiosisResistant starchClostridiumEndocrinologyInsulin resistanceMicrobiologyInternal medicineObesityBiochemistryFirmicutesMedicineBacteriaFermentationGenisteinDaidzein16S ribosomal RNAGeneStarchGeneticsGut microbiota and healthDiet and metabolism studiesDietary Effects on Health