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Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease

Ganqiang Liu, Jiajie Peng, Zhixiang Liao, Joseph J. Locascio, Jean‐Christophe Corvol, Frank Zhu, Xianjun Dong, Jodi Maple‐Grødem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H. Growdon, Albert Y. Hung, Michael A. Schwarzschild, Michael T. Hayes, Anne‐Marie Wills, Todd M. Herrington, Bernard Ravina, Ira Shoulson, Pille Taba, Sulev Kõks, Thomas G. Beach, Florence Cormier‐Dequaire, Guido Alves, Ole‐Bjørn Tysnes, Joel S. Perlmutter, Peter Heutink, Sami S. Amr, Jacobus van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A. Barker, Caroline H. Williams‐Gray, Johan Marinus, Jacobus J. van Hilten, Clemens R. Scherzer

2021Nature Genetics140 citationsDOIOpen Access PDF

Topics & Concepts

BiologyDementiaHazard ratioDiseaseLocus (genetics)Genome-wide association studyOncologyPopulationInternal medicineBioinformaticsGeneticsSingle-nucleotide polymorphismGenotypeMedicineGeneConfidence intervalEnvironmental healthGenomic variations and chromosomal abnormalitiesParkinson's Disease Mechanisms and TreatmentsGenetic Associations and Epidemiology
Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease | Litcius