The Role of Omega-3 in Attenuating Cardiac Remodeling and Heart Failure through the Oxidative Stress and Inflammation Pathways
Taline Lazzarin, Danilo Martins, Raquel Simões Ballarin, Marina Gaiato Monte, Marcos Ferreira Minicucci, Bertha Furlan Polegato, Leonardo Antônio Mamede Zornoff
Abstract
Cardiac remodeling is defined as molecular, cellular, and interstitial changes that manifest clinically as alterations in the size, shape, and function of the heart. Despite the pharmacological approaches, cardiac remodeling-related mortality rates remain high. Therefore, other therapeutic options are being increasingly studied. This review highlights the role of omega-3 as an adjunctive therapy to attenuate cardiac remodeling, with an emphasis on its antioxidant and anti-inflammatory actions.
Topics & Concepts
Heart failureInflammationOxidative stressMedicineVentricular remodelingCardiac function curveCardiologyBioinformaticsInternal medicineBiologyFatty Acid Research and HealthPeroxisome Proliferator-Activated ReceptorsEicosanoids and Hypertension Pharmacology