Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion
Ayala Tovy, Jaime M. Reyes, Michael C. Gundry, Lorenzo Brunetti, Henry Lee-Six, Mia Petljak, Hyun Jung Park, Anna Guzman, Carina Rosas, Aaron R. Jeffries, Emma L. Baple, Jonathan Mill, Andrew H. Crosby, Valerie Sency, Baozhong Xin, Heather E. Machado, Danielle Castillo, Jeffrey N. Weitzel, Wei Li, Michael R. Stratton, Peter J. Campbell, Heng Wang, Mathijs A. Sanders, Margaret A. Goodell
Topics & Concepts
BiologyEpigeneticsDNA methylationMutantSomatic cellDNA methyltransferaseGermlineHaematopoiesisGeneticsMethylationGermline mutationStem cellMutationDNACell biologyGeneGene expressionEpigenetics and DNA MethylationAcute Myeloid Leukemia ResearchCancer Genomics and Diagnostics