Hepatocyte-derived exosomal miR-27a activates hepatic stellate cells through the inhibition of PINK1-mediated mitophagy in MAFLD
Xin Luo, Zixin Xu, Jun-Cheng Wu, Shengzheng Luo, Mingyi Xu
Abstract
, exosomes derived from miR-27a-knockdown HCs could not facilitate the abovementioned deteriorating effects. In conclusion, lipotoxic HC-exosomal miR-27a plays a pivotal role in inhibiting mitophagy and in promoting MAFLD-related liver fibrosis by negatively regulating PINK1 expression.
Topics & Concepts
MitophagyHepatic stellate cellHepatocyteAutophagyCell biologyPINK1ChemistryCancer researchMedicineInternal medicineBiologyIn vitroBiochemistryApoptosisLiver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and DiseaseLiver Disease and Transplantation