The transcription factor E2A activates multiple enhancers that drive <i>Rag</i> expression in developing T and B cells
Kazuko Miyazaki, Hitomi Watanabe, Genki Yoshikawa, Kenian Chen, Reiko Hidaka, Yuki Aitani, Kai Osawa, Rie Takeda, Yotaro Ochi, Shizue Tani‐ichi, Takuya Uehata, Osamu Takeuchi, Koichi Ikuta, Seishi Ogawa, Gen Kondoh, Yin C. Lin, Hiroyuki Ogata, Masaki Miyazaki
Abstract
Distinct enhancer modules drive expression of Rag genes during T and B cell development (see the related Focus by Wang and Rothenberg ).
Topics & Concepts
EnhancerBiologyTranscription factorGeneRecombination-activating geneChromatinB cellCell biologyRegulation of gene expressionGeneticsT cellLineage (genetic)T-cell receptorAcquired immune systemAntibodyAntigenRecombinationImmune systemT-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses