Omics technologies to understand drug toxicity mechanisms
Nhan Nguyen, Danyel Jennen, Jos Kleinjans
Abstract
Drug side effects are an important study subject in pharmacology. Recent omics technologies provide a range of omics data and help to understand the biological mechanisms involved in drug effects. These modern technologies provide significant support to all biological disciplines, including drug toxicology. In this review, we provide an overview the use of omics applications to understand drug side effects at the molecular level. We discuss by available omics technologies, their possible uses, as well as their advantages and limitations.
Topics & Concepts
OmicsDrug discoveryDrugDrug toxicityData scienceComputational biologyPharmacologyBioinformaticsComputer scienceMedicineBiologyMetabolomics and Mass Spectrometry StudiesComputational Drug Discovery MethodsPharmacogenetics and Drug Metabolism